Current surgical intervention for patients with osteoarthritis of the hip usually involves total hip replacement surgery, with the loss of large sections of bone and cartilage. However, improved imaging techniques to detect the disease earlier and moves towards less invasive surgery has led to interest in more conservative alternatives. One option is tissue substitution, where only the diseased tissue is substituted. The research conducted in this RAEng fellowship will explore these novel alternative tissue substitution options.
A whole hip joint cartilage degradation simulator system will be devised to allow preclinical investigation of these solutions. This is ambitions, requiring the development of a tissue cell to create an environment to maintain cartilage viability for medium-duration tests. The wear and degradation of cartilage will be assessed following articulation.
Partial tissue substitution and tissue engineered constructs to repair the degenerated cartilage layer will be investigated through future collaborative projects with other groups who are currently developing new biomaterials and matrices.
Dr Williams is currently supervising the following research student(s):
|James Anderson||Development of a patho-physiology based morphological model for avascular necrosis of the femoral head|
|Hazel Fermor||Engineering of natural cartilage substitution materials|
|Nicholas Gowland||Wear and biological activity of antioxidant polyethylenes for total hip replacement|
|Dawn Groves||The effect of the natural acetabulum's geometry on hip osteoarthritis: a clinical and tribological evaluation|
|Richard Senior||Functional investigation of tissue engineered cartilage|
|Mahsa Shahi Avadi|
or you can display a fuller, categorised list
|Brockett CL; John G; Williams S; Isaac G; Jin Z; Fisher J Ceramic-on-carbon fibre reinforced poly-ether-ether ketone hip replacements: A novel low wear bearing. Journal of Biomedical Materials Research Part B: Applied Biomaterials, Accepted.|
|Brockett CL; Williams S; Jin Z; Fisher J; Isaac GH Squeaking Hip Arthroplasties: A Tribological Phenomenon. Journal of Arthroplasty, vol. 28, pp.90-97. 2013.||DOI|
|Fermor HL; McLure SWD; Taylor SD; Russell SL; Williams S; Fisher J; Ingham E Biological, biochemical and biomechanical characterisation of cartilage from the porcine, bovine and ovine hip and knee in: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, pp.66-66. 2012.||LINK|
|Taylor SD; Tsiridis E; Ingham E; Jin Z; Fisher J; Williams S Comparison of human and animal femoral head chondral properties and geometries. Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine, vol. 226, pp.55-62. 2012.||LINK
|Taylor SD; Ingham E; Jin Z; Fisher J; Williams S; Tsiridis E Comparison of human and animal femoral head chondral properties and geometries. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, vol. 226, pp.55-62. 2012.||DOI|
|Senior RA; Plainfosse M; Crawford A; Williams S; Jin ZM; Fisher J; Hatton PV Increased viscosity media for use in bioreactor culture to prepare tissue engineered cartilage constructs for tribo-mechanical testing in: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 6, pp.71-72. 2012.||LINK|