BHRC Senior Translational Research Fellow in Cardiac and Vascular Tissue
Investigation of mesothelial cell interactions with Permacol® In Vitro
Industrial Sponsor: Tissue Service Ltd
Supervisor: Professor Eileen Ingham, Professor John Fisher, Dr J Proffitt (TSL)
Permacol® is physically smooth and does not provoke an immune rejection. Tissue Science Laboratories have evidence from In vivo studies to indicate that when Permacol® is used as a tissue patch in the abdominal cavity, that few adhesions are formed an these are usually associated with the suture points of the material in the abdominal wall. It has been proposed that the smooth surface of Permacol® and its covering with mesothelium elicit few adhesions on the surface presented towards the cavity. It has been suggested that with those implants that provoke more adhesions, the material may be rougher (or more immunogenic) and therefore adhesions could occur before the material can be covered with mesothelium. In more sever cases, the material may provoke such a foreign body reaction that adhesions are inevitable. It is therefore proposed that Permacol® has advantages over other implantable biomaterials.
The aims of this study were to determine the capacity of mesothelial cells to adhere to, proliferate on and cover the surface of Permacol® compare to other implantable biomaterials. The capacity of Permacol® to induce and anti-inflammatory, fibrinolytic functional mesothelial cells phenotype will be investigated as will the nature of fibrin cots formed on the surface of Permacol® compared to other implantable biomaterials.
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|Tatterton M; Wilshaw S-P; Ingham E; Homer-Vanniasinkam S Tissue engineering a small diameter vascular graft-cell seeding of a decellularised porcine arterial scaffold in: BRITISH JOURNAL OF SURGERY, vol. 100, pp.15-15. 2013.||LINK|
|Owen K; Wilshaw S-P; Ingham E; Homer-Vanniasinkam S; Bojar RA; Berry H Assessment of the antimicrobial activity of acellular vascular grafts. European Journal of Vascular and Endovascular Surgery, vol. 43, pp.573-581. 2012.||DOI|
|Owen K; Wilshaw SP; Homer-Vanniasinkam S; Bojar RA; Berry H; Ingham E Assessment of the antimicrobial activity of acellular vascular grafts.. European Journal of Vascular and Endovascular Surgery, vol. 43, pp.573-581. 2012.||LINK
|Guilliatt R; Davies R; Wilshaw SP; Aggeli A; Ingham E Biocompatibility and haemocompatibility of self-assembling peptides. Journal of Tissue Engineering and Regenerative Medicine, vol. 6, pp.218-219. 2012.||LINK|
|Wilshaw SP; Rooney P; Berry H; Kearney JN; Homer-Vanniasinkam S; Fisher J; Ingham E Development and characterization of acellular allogeneic arterial matrices.. Tissue Engineering Part A, vol. 18, pp.471-483. 2012.||LINK
|Owen K; Wilshaw SP; Homer-Vanniasinkam S; Bojar RA; Berry H; Ingham E Initial wash-out of antimicrobial cocktails from acellular vascular grafts. Journal of Tissue Engineering and Regenerative Medicine, vol. 6, pp.145-146. 2012.||LINK|